This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
MA5-14579 targets Prostate Specific Membrane Antigen in IHC (P) applications and shows reactivity with Human samples.
The MA5-14579 immunogen is c-terminal of Prostate Specific Membrane Antigen.
Prostate Specific Membrane Antigen (PSMA) is a surface glycoprotein with restricted expression to normal prostate tissue, primary and metastatic prostate cancer and the neovasculature of various nonprostatic epithelial malignancies. Overexpression of PSMA is correlated with high tumor grade, non-diploid tumors, and advanced tumor stage. Even though PSA is useful in identifying the prostate origin of cancers, PSMA shows moderate to strong positivity in one-half of the cells per case that show relatively poor PSA staining, and is excellent in differentiating between prostatic adenocarcinoma and urothelial carcinoma. PSMA is expressed in 94.3% to 100% of primary and 57.7%–100% of metastatic prostatic carcinomas. PSMA is recognized as a viable target for cancer therapy.
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Protein Aliases: Cell growth-inhibiting gene 27 protein; cell growth-inhibiting protein 27; FGCP; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; GCPII; glutamate carboxylase II; Glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; Membrane glutamate carboxypeptidase; mGCP; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; prostate specific membrane antigen variant F; Prostate-specific membrane antigen; PSM; Pteroylpoly-gamma-glutamate carboxypeptidase
Gene Aliases: FGCP; FOLH; FOLH1; GCP2; GCPII; GIG27; mGCP; NAALAD1; NAALAdase; PSM; PSMA
UniProt ID: (Human) Q04609
Entrez Gene ID: (Human) 2346
Molecular Function: receptor