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Product Details
H00143471-M03A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2E3
Immunogen
PSMA8 (NP_653263, 143 a.a. approximately 242 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: GFDDDGISRL YQTDPSGTYH AWKANAIGRS AKTVREFLEK NYTEDAIASD SEAIKLAIKA LLEVVQSGGR NIELAIIRRN QPLKMFSAKE VELYVTEIEK
Target Information
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha4s; proteasome (prosome, macropain) subunit, alpha type, 8; Proteasome alpha 4 subunit; proteasome alpha 8 subunit; proteasome subunit alpha type 7-like protein variant 1; proteasome subunit alpha type-7-like; Proteasome subunit alpha type-8; Proteasome subunit alpha-type 7-like; Proteasome subunit alpha-type 8
Gene Aliases: 2410072D24Rik; PSMA7L; PSMA8; RGD1311659
UniProt ID: (Human) Q8TAA3, (Mouse) Q9CWH6
Entrez Gene ID: (Human) 143471, (Mouse) 73677, (Rat) 364814
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
proteolysis
ubiquitin-dependent protein catabolic process
proteasomal ubiquitin-independent protein catabolic process
proteolysis involved in cellular protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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