The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
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Protein Aliases: 26 kDa prosomal protein; HsBPROS26; HsN3; Macropain beta chain; Multicatalytic endopeptidase complex beta chain; PROS26; proteasome (prosome, macropain) subunit, beta type, 4; proteasome beta 4 subunit; Proteasome beta chain; Proteasome chain 3; Proteasome subunit beta type-4; proteasome subunit HsN3; proteasome subunit, beta type, 4; PSMB4; testis tissue sperm-binding protein Li 79P
Gene Aliases: HN3; HsN3; PROS-26; PROS26; PSMB4
UniProt ID: (Human) P28070
Entrez Gene ID: (Human) 5692