This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody reacts with the C-terminus of the human and rodent PTB protein.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein, PTB (polypyrimidine tract binding protein; PTBP1), encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar compartment (PNC), a structure localized at the periphery of the nucleolus. Thus far PTB as well as small RNAs (i.e, Y RNAs, MRP RNA, and Rnase P H1 RNA) have been identified in the PNC. Studies conducted to characterize the structure of the PNC, revealed that RNA binding may be required for PTB to be localized in the PNC. Alternatively spliced transcript variants encoding different isoforms have been described.
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Protein Aliases: 57 kDa RNA-binding protein PPTB-1; heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNP-I; HNRNPI; HNRPI; polypyrimidine t; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract-binding protein 1; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; pyrimidine binding protein 1; pyrimidine binding protein 2; RNA-binding protein
Gene Aliases: AA407203; AL033359; HNRNP-I; HNRNPI; HNRPI; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; Pybp; Pybp1; Pybp2