Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Mouse , Rat , Human|
|Published species reactivity||Virus , Human , Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human PTB protein.|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||1-3 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Methods for the characterization of stress granules in virus infected cells.
32-4800 was used in western blot to discuss methods for the characterization of stress granules in virus infected cells
|Panas MD,Kedersha N,McInerney GM||Methods (San Diego, Calif.) (90:57)||2015|
PTB deficiency causes the loss of adherens junctions in the dorsal telencephalon and leads to lethal hydrocephalus.
||Shibasaki T,Tokunaga A,Sakamoto R,Sagara H,Noguchi S,Sasaoka T,Yoshida N||Cerebral cortex (New York, N.Y. : 1991) (23:1824)||2013|
Translation of Myocyte Enhancer Factor-2 is induced by hypertrophic stimuli in cardiomyocytes through a Calcineurin-dependent pathway.
32-4800 was used in western blot to report that MEF2 protein levels are regulated at the translational level and determine myocyte size during hypertrophy.
|Ye J,Cardona M,Llovera M,Comella JX,Sanchis D||Journal of molecular and cellular cardiology (53:578)||2012|
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.
32-4800 was used in western blot to investigate the role of miRNAs in amyloid precursor protein splicing in vivo.
|Smith P,Al Hashimi A,Girard J,Delay C,Hébert SS||Journal of neurochemistry (116:240)||2011|
The leader protein of Theiler's virus interferes with nucleocytoplasmic trafficking of cellular proteins.
||Delhaye S,van Pesch V,Michiels T||Journal of virology (78:4357)||2004|
HNRPI, AL033359, PTB-T, Pybp1, Pybp2, PTB, AA407203, Ptb, HNRNPI, Pybp, HNRNP-I, pPTB, PTB2, PTB3, PTB-1, PTB4
heterogeneous nuclear ribonucleoprotein I, hnRNP I, polypyrimidine tract-binding protein 1, pyrimidine binding protein 1, pyrimidine binding protein 2, 57 kDa RNA-binding protein PPTB-1, RNA-binding protein, heterogeneous nuclear ribonucleoprotein polypeptide I, polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I), HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB, polypyrimidine t