|Tested species reactivity||Horse, Human, Marsupial, Mouse, Non-human primate, Bovine, Dog|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (127 DSPLYIFDSSYGEHPKRR 144) of PTDSR protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.25-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PTDSR, also known as jumonji domain containing 6, is a 403 amino acid containing nuclear protein belonging to the PTDSR family with a JmjC domain. Like other JmjC domain-containing proteins PTDSR is predicted to function as protein hydroxylases or histone demethylases. PTDSR is an arginine demethylase which demethylates histone H3 at 'Arg-3' and histone H4 at 'Arg-4' and is known to function in the differentiation of multiple organs during embryogenesis, and regulate hematopoietic differentiation and macrophage cytokine responses. First identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, PTDSR was later indicated not to directly function in the clearance of apoptotic cells. It is ubiquitously expressed in most of the tissues and upregulated in patients with chronic pancreatitis and upon cytokine treatment, but not upon TNF-alpha treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.