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|Tested species reactivity||Human , Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant fragment of PTEN expressed in E. Coli.|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.03% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1/200 - 1/400|
|Western Blot (WB)||1/500 - 1/2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA5-15560 targets PTEN in ICC, IF, FACS, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15560 immunogen is purified recombinant fragment of PTEN expressed in E. Coli.
MA5-15560 detects PTEN which has a predicted molecular weight of approximately 54kDa.
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BZS, AI463227, DEC, CWS1, 10q23del, MMAC1, A130070J02Rik, B430203M17Rik, GLM2, 2310035O07Rik, PTEN1, TEP1, MHAM
mitochondrial PTENalpha, mutated in multiple advanced cancers 1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1 phosphatase and tensin homolog deleted on chromosome 10, phosphatase and tensin-like protein, Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, MMAC1, TEP1