Invitrogen

PTGIR (extracellular) Polyclonal Antibody

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PTGIR (extracellular) Antibody in Western Blot (WB) — Western blot analysis of human Jurkat T-cell leukemia cell lysate (lanes 1 and 4), human THP-1 monocytic leukemia cell lysate (lanes 2 and 5) and human MEG-01 megakaryoblastic leukemia cell lysate (lanes 3 and 6) with PTGIR (extracellular) polyclonal antibody (Product # PA5-77695) using a dilution of 1:200.

PTGIR (extracellular) Antibody in Flow Cytometry (Flow) — Flow cytometry analysis of human MEG-01 megakaryoblastic leukemia cells using polyclonal PTGIR (extracellular) antibody (Product # PA5-77695) with a dilution of 1:20 followed by a goat anti-rabbit-AlexaFluor-647 secondary antibody.

PTGIR (extracellular) Antibody — (C)TQAIAPDSREMGD, corresponding to amino acid residues 290-302 of rat Prostanoid Prostacyclin receptor

Product Details

Tested Applications

Dilution

Flow Cytometry (Flow)

1:200-1:2000

Immunofluorescence (IF)

Assay-Dependent

Western Blot (WB)

1:200-1:2000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide (C)TQAIAPDSREMGD, corresponding to amino acid residues 290-302 of rat Prostanoid Prostacyclin receptor

Conjugate

Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

RRID

AB_2736479

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.

Reconstitute using 50 uL deionized water.

Target Information

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: PGI receptor; PGI2 receptor; Prostacyclin receptor; prostaglandin I receptor (IP); Prostaglandin I2 receptor; Prostanoid IP receptor; Prostanoid Prostacyclin Receptor (extracellular)

Gene Aliases: IP; PGI2; PRIPR; PTGIR

UniProt ID: (Human) P43119, (Mouse) P43252, (Rat) P43253

Entrez Gene ID: (Human) 5739, (Mouse) 19222, (Rat) 292661

Molecular Function: G-protein coupled receptor receptor

Function(s)

inflammatory response G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of cAMP biosynthetic process response to lipopolysaccharide positive regulation of GTPase activity positive regulation of cAMP-mediated signaling negative regulation of smooth muscle cell proliferation cellular response to prostaglandin D stimulus signal transduction G-protein coupled receptor signaling pathway

Process(es)

guanyl-nucleotide exchange factor activity prostacyclin receptor activity signal transducer activity G-protein coupled receptor activity

PTGIR (extracellular) Polyclonal Antibody

Product Details

Product Specific Information

Target Information

Bioinformatics

Material safety data sheets (MSDS)

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