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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • COX1 Antibodies

          Proteintech

          PTGS1 Monoclonal Antibody (1F12G7)

          View all (20) COX1 antibodies

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          Cite PTGS1 Monoclonal Antibody (1F12G7)

          • Antibody Testing Data (2)
          PTGS1 Antibody in Immunocytochemistry (ICC/IF)
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          PTGS1 Antibody in Immunocytochemistry (ICC/IF)
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          FIGURE: 1 / 2

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          PTGS1 Antibody (67346-1-IG) in ICC/IF

          Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using 67346-1-Ig (PTGS1 antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          PTGS1 Antibody in Immunocytochemistry (ICC/IF)
          PTGS1 Antibody in Western Blot (WB)

          Product Details

          67346-1-IG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:3,000
          -

          Immunocytochemistry (ICC/IF)

          1:100
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG2b

          Class

          Monoclonal

          Type

          Antibody

          Clone

          1F12G7

          Immunogen

          PTGS1 Fusion Protein Ag28280

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • CoraLite Plus 488
          • Request custom conjugation

          Form

          Liquid

          Concentration

          1000 µg/mL

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice

          Product Specific Information

          Aliquoting is unnecessary for -20°C storage.

          Target Information

          PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: COX-1; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; Prostaglandin G/H synthase 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

          View more View less

          Gene Aliases: COI; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS; PTGS1

          View more View less

          UniProt ID: (Human) P23219

          View more View less

          Entrez Gene ID: (Human) 5742

          View more View less

          Function(s)
          peroxidase activity prostaglandin-endoperoxide synthase activity lipid binding heme binding metal ion binding dioxygenase activity oxygenase
          Process(es)
          prostaglandin biosynthetic process lipid metabolic process xenobiotic metabolic process inflammatory response response to oxidative stress aging learning memory regulation of blood pressure response to organonitrogen compound negative regulation of norepinephrine secretion sensory perception of pain cyclooxygenase pathway negative regulation of epinephrine secretion maintenance of blood-brain barrier regulation of cell proliferation positive regulation of vasoconstriction positive regulation of smooth muscle contraction response to corticosterone oxidation-reduction process response to fatty acid cellular oxidant detoxification
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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