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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:3,000 | - |
Immunocytochemistry (ICC/IF) |
1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
1F12G7 |
Immunogen |
PTGS1 Fusion Protein Ag28280 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1000 µg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Aliquoting is unnecessary for -20°C storage.
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: COX-1; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; Prostaglandin G/H synthase 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Gene Aliases: COI; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219
Entrez Gene ID: (Human) 5742
Molecular Function:
oxygenase
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