MA5-15669 targets PTK7 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15669 immunogen is purified recombinant fragment of human PTK7 expressed in E. Coli.
MA5-15669 detects PTK7 which has a predicted molecular weight of approximately 118kDa.
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.
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Protein Aliases: CCK-4; CCK4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7; PTK7 protein tyrosine kinase 7; Tyrosine-protein kinase-like 7
Gene Aliases: CCK-4; CCK4; PTK7
UniProt ID: (Human) Q13308
Entrez Gene ID: (Human) 5754