This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
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Protein Aliases: placental; protein tyrosine phosphatase; protein tyrosine phosphatase 1B; protein tyrosine phosphatase, placental; Protein-tyrosine phosphatase 1B; PTP-1B; PTP1B; Tyrosine-protein phosphatase non-receptor type 1
Gene Aliases: PTP1B; PTPN1
UniProt ID: (Human) P18031
Entrez Gene ID: (Human) 5770