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|Tested species reactivity||Human|
|Host / Isotype||E.coli|
|Storage buffer||25mM tris HCl, pH 8.0, with 50% glycerol, 1mM DTT, 2mM EDTA, 0.01M L-glutathione, 0.05% Tween 20, 75mM NaCl|
|Tested Applications||Dilution *|
|Control (Ctrl)||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Tyrosine-protein phosphatase, non-receptor type 1 (PTP1B) also know as Protein-tyrosine phosphatase 1B, PTPN1 is a PTP (protein tyrosine phosphatase) first isolated from human placenta. The protein is unrelated to other known phosphatases but is similar to common leukocyte antigen (CD45) and to LAR a homolog of the neural adhesion molecule NCAM. PTP1B negatively regulates insulin sensitivity by dephosphorylating the insulin receptor. Akt is a ser/thr kinase effector of insulin signaling that phosphorylates substrates at the consensus motif RXRXXS/T. PTP1B contains the Akt phosphorylation motif (RYRDVS50), and PTP1B (but not mutants with substitutions for Ser50) are phosphorylated by Akt. Insulin stimulation also causes a significant increase in phosphorylation of PTP1B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
protein tyrosine phosphatase, placental; protein-tyrosine phosphatase 1B; PTPN1