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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant human protein purified from E.coli|
|Purification||Ammonium sulfate precipitation|
|Storage buffer||HEPES with 0.15M NaCl, 0.01% BSA, 50% glycerol|
|Contains||0.03% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control for this product is Bosc23 cell lysate transfected with Myc/His/PEZ.
Protein-tyrosine phosphatase 14 (PTPN14/PTPD2/PEZ) is a 130kDa multidomain cytosolic protein, and belongs to the NT6 subtype of PTPs. It is characterized by an N-terminal FERM domain (Band 4.1, ezrin, radixin, moesin homology) and a C-terminal PTP domain. Pez (Phosphatase with ezrin domain) may play a role in regulating endothelial cell proliferation during vascular injury and angiogenesis. B-Catenin, a central component of adherens junctions, has been identified as a PTPN14 substrate. TGF, which inhibits cell proliferation but not migration, also inhibits translocation of PTPN14 from the cytosol to the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
cytoskeletal-associated protein tyrosine phosphatase; protein-tyrosine phosphatase pez; tyrosine-protein phosphatase non-receptor type 14
PEZ; PTP36; PTPD2; PTPN14