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PTPN22 Monoclonal Antibody (OTI6B1), TrueMAB™

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PTPN22 Monoclonal Antibody (OTI6B1), TrueMAB™

Product Details

TA810177

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI6B1

Immunogen

Human recombinant protein fragment corresponding to amino acids 359-449 of human PTPN22 produced in E.coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; lymphoid-specific protein tyrosine phosphatase; LYP3; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; PTPN22.8; tyrosine-phosphatase; unnamed protein product

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Gene Aliases: LYP; LYP1; LYP2; PEP; PTPN22.5; PTPN22.6; PTPN8

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UniProt ID: (Human) Q9Y2R2

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Entrez Gene ID: (Human) 26191

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Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding phosphatase activity SH3 domain binding kinase binding ubiquitin protein ligase binding
Process(es)
negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression T cell differentiation lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide negative regulation of interleukin-6 production negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production regulation of natural killer cell proliferation positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway phosphoanandamide dephosphorylation negative regulation of JUN kinase activity regulation of innate immune response T cell receptor signaling pathway regulation of B cell receptor signaling pathway regulation of T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation positive regulation of ERK1 and ERK2 cascade negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to muramyl dipeptide positive regulation of NLRP3 inflammasome complex assembly regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination negative regulation of p38MAPK cascade
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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