This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein Aliases: 31 kDa transforming protein; 31 kDa-transforming protein; hCG_25181; hematopoietic transcription factor PU.1; SFFV proviral integration 1; SFFV proviral integration 1 protein; spleen focus forming virus (SFFV) proviral integration oncogene spi1; spleen focus forming virus proviral integration oncogene spi1; Transcription factor PU.1
Gene Aliases: Dis-1; Dis1; OF; PU.1; Sfpi-1; SFPI1; SPI-1; SPI-A; SPI1; Tcfpu1; Tfpu.1
Molecular Function: winged helix/forkhead transcription factor