PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
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Protein Aliases: BBC3; Bcl-2 binding component 3; Bcl-2-binding component 3; BCL2 binding component 3; BH3-only; JFY-1; p53 up regulated modulator of apoptosis; p53 up-regulated modulator of apoptosis; PUMA/JFY1
Gene Aliases: BBC3; JFY-1; JFY1; PUMA; PUMA/JFY1