This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.
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Protein Aliases: P5C reductase 1; proliferation-inducing protein 45; Pyrroline-5-carboxylate reductase 1, mitochondrial
Gene Aliases: ARCL2B; ARCL3B; P5C; P5CR; PIG45; PP222; PRO3; PYCR; PYCR1
UniProt ID: (Human) P32322
Entrez Gene ID: (Human) 5831