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OriGene
PYDC1 Monoclonal Antibody (OTI11C3), TrueMAB™
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FIGURE: 1 / 1
PYDC1 Antibody (CF803556) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PYDC1 (RC211240, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PYDC1. Positive lysates LY407263 (100 µg) and LC407263 (20 µg) can be purchased separately from OriGene.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
CF803556
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI11C3
Immunogen
Full length human recombinant protein of human PYDC1 produced in E.coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
ASC2 associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cellular POP1; cPOP1; PAAD containing protein; PAAD-only protein 1; PYC1; PYD (pyrin domain) containing 1; Pyrin domain-containing protein 1; pyrin family member; Pyrin-only protein 1; unnamed protein product
Gene Aliases: ASC2; ASCI; cPOP1; POP1; PYC1; PYDC1
UniProt ID: (Human) Q8WXC3
Entrez Gene ID: (Human) 260434
immune system process
negative regulation of signal transduction
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-1 beta production
positive regulation of interleukin-1 beta production
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
defense response to other organism
negative regulation of NLRP3 inflammasome complex assembly
negative regulation of interleukin-1-mediated signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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