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ASC2 associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cellular POP1; cPOP1; PAAD-only protein 1; PYD (pyrin domain) containing 1; Pyrin domain-containing protein 1; Pyrin-only protein 1
Gene Aliases: ASC2; ASCI; cPOP1; POP1; PYC1; PYDC1
UniProt ID: (Human) Q8WXC3
Entrez Gene ID: (Human) 260434
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