Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
75-179-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N145/20
Immunogen
Fusion protein amino acids 381-590 (C-terminus) of mouse GRK5 (accession number Q8VEB1) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
GRK5 and GRK6 (G protein-coupled receptor kinases 5 and 6) are members of the GRK family of serine/threonine kinases. These kinases play a crucial role in the regulation of G protein-coupled receptors (GPCRs), which are involved in many physiological processes and are targets for a large number of drugs. Dysregulation of GRK5 and GRK6 has been implicated in various diseases, such as heart failure, hypertension, and certain psychiatric disorders. Their role in GPCR regulation makes them potential targets for therapeutic intervention in these conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Alpha-CP4; FP2025; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK5; G protein-coupled receptor kinase GRK6; G-protein coupled receptor kinase 6; Poly(rC)-binding protein 4
Gene Aliases: 1200003L19Rik; AlphaCP-4; GPRK5; GPRK6; GRK5; GRK6; Pcbp4
UniProt ID: (Human) P34947, (Human) P43250, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) O70293, (Mouse) P57724
Entrez Gene ID: (Human) 2869, (Human) 2870, (Mouse) 14773, (Rat) 59075, (Mouse) 26385, (Rat) 59076, (Mouse) 59092
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
protein kinase C binding
protein binding
ATP binding
phospholipid binding
beta-adrenergic receptor kinase activity
nucleotide binding
protein kinase activity
lipid binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
desensitization of G-protein coupled receptor protein signaling pathway
apoptotic process
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
Wnt signaling pathway
response to drug
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
protein phosphorylation
negative regulation of anion channel activity
signal transduction
phosphorylation
termination of G-protein coupled receptor signaling pathway
negative regulation of mRNA splicing, via spliceosome
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support