Antibodies Inc

Pan-MAGUK Monoclonal Antibody (K28/86), FL594

View all (5) Pan-MAGUK antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

75-029-FL594

Applications
Tested Dilution
Publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat, Xenopus, Zebrafish

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

K28/86

Immunogen

Fusion protein amino acids 77-299 of human PSD-95/SAP90 produced recombinantly in E. Coli.
View immunogen

Conjugate

FL594 FL594 FL594

Excitation/Emission Max

594/615 nm

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

For maximum recovery of product, centrifuge the vial prior to removing the cap.

Target Information

Pan-MAGUK refers to the collective group of Membrane-Associated Guanylate Kinase (MAGUK) family proteins, which are scaffolding proteins involved in organizing signaling complexes at cellular membranes. These proteins play critical roles in synaptic signaling, cell adhesion, and maintaining the structure of tight junctions. Dysregulation of MAGUK proteins has been linked to various neurological disorders and cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-110; discs large 2; discs large homolog 1; discs large homolog 1, scribble cell polarity complex component; discs large homolog 2; discs large homolog 3; discs large homolog 4; discs, large homolog 1; discs, large homolog 1 (Drosophila) transcript variant 6-v1; discs, large homolog 1 (Drosophila) transcript variant 6-v2; discs, large homolog 2; discs, large homolog 2, chapsyn-110; discs, large homolog 3; discs, large homolog 4; Disks large homolog 1; Disks large homolog 2; Disks large homolog 3; Disks large homolog 4; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; membrane associated guanylate kinase; MAGUK; Neuroendocrine-DLG; post-synaptic density protein 95; Postsynaptic density protein 93; Postsynaptic density protein 95; Postsynaptic density protein PSD-93; presynaptic protein SAP97; protein phosphatase 1, regulatory subunit 58; protein phosphatase 1, regulatory subunit 82; PSD-93; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD-95/SAP90-related protein 1; SAP-102; SAP-90; SAP-97; SAP-97A; SAP102; SAP97A; Synapse-associated protein 102; Synapse-associated protein 90; Synapse-associated protein 97; Synapse-associated protein 97A; synapse-associated protein SAP90; synaptic density protein PSD-93; Tax interaction protein 15; XLMR

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Gene Aliases: A330103J02Rik; B130052P05Rik; B230218P12Rik; B330007M19Rik; chapsyn-110; dJ1061C18.1.1; DLG1; DLG2; DLG3; DLG4; DLGH1; Dlgh2; Dlgh3; Dlgh4; E-dlg/SAP97; fa66c08; fa66e02; fd02c12; fu95c12; Gm1197; hdlg; im:7138640; KIAA1232; mKIAA1232; mKIAA4187; MRX; MRX90; NEDLG; PPP1R58; PPP1R82; PSD-93; PSD-95; PSD93; PSD95; SAP-90; SAP-97; SAP-97A; SAP102; SAP90; SAP90A; SAP97; si:ch211-276g21.1; wu:fa66c08; wu:fa66e02; wu:fc34d02; wu:fd02c12; wu:fu95c12; XLMR; zgc:55810

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UniProt ID: (Human) Q12959, (Human) Q15700, (Human) Q92796, (Human) P78352, (Rat) Q62696, (Mouse) Q811D0, (Mouse) Q91XM9, (Rat) Q63622, (Rat) Q62936, (Mouse) P70175, (Rat) P31016, (Mouse) Q62108, (Zebrafish) Q5PYH6, (Zebrafish) Q5PYH7

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Entrez Gene ID: (Human) 1739, (Human) 1740, (Human) 1741, (Human) 1742, (Rat) 25252, (Mouse) 13383, (Mouse) 23859, (Rat) 64053, (Rat) 58948, (Mouse) 53310, (Rat) 29495, (Mouse) 13385, (Zebrafish) 114446, (Zebrafish) 497638, (Zebrafish) 564081, (Western clawed frog) 779559, (Zebrafish) 100000823

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Function(s)
guanylate kinase activity phosphoprotein phosphatase activity protein binding protein C-terminus binding cytoskeletal protein binding ligand-gated ion channel activity potassium channel regulator activity protein kinase binding phosphatase binding mitogen-activated protein kinase kinase binding protein complex scaffold ionotropic glutamate receptor binding ion channel binding L27 domain binding cadherin binding involved in cell-cell adhesion kinase binding protein phosphatase binding PDZ domain binding ubiquitin protein ligase binding Ras guanyl-nucleotide exchange factor activity beta-1 adrenergic receptor binding D1 dopamine receptor binding P2Y1 nucleotide receptor binding protein complex binding acetylcholine receptor binding neuroligin family protein binding scaffold protein binding protein heterodimerization activity protein domain specific binding receptor binding glutamate receptor binding structural molecule activity neurexin family protein binding scaffold/adaptor protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis immunological synapse formation endothelial cell proliferation lens development in camera-type eye T cell cytokine production protein dephosphorylation actin filament organization mitotic cell cycle checkpoint establishment or maintenance of cell polarity chemical synaptic transmission nervous system development positive regulation of cell proliferation regulation of cell shape viral process single organismal cell-cell adhesion peristalsis positive regulation of actin filament polymerization cortical actin cytoskeleton organization astral microtubule organization membrane raft organization regulation of myelination activation of protein kinase activity ion transmembrane transport cellular protein complex localization T cell activation negative regulation of T cell proliferation regulation of membrane potential amyloid precursor protein metabolic process receptor clustering positive regulation of potassium ion transport cortical microtubule organization establishment or maintenance of epithelial cell apical/basal polarity negative regulation of mitotic cell cycle GMP metabolic process GDP metabolic process reproductive structure development embryonic skeletal system morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation establishment of centrosome localization negative regulation of protein kinase B signaling hard palate development negative regulation of ERK1 and ERK2 cascade bicellular tight junction assembly protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane receptor localization to synapse regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport negative regulation of p38MAPK cascade negative regulation of phosphatase activity sensory perception of pain establishment of planar polarity negative regulation of cell proliferation MAPK cascade negative regulation of receptor internalization protein complex assembly signal transduction positive regulation of cytosolic calcium ion concentration learning synaptic vesicle maturation social behavior protein localization to synapse locomotory exploration behavior positive regulation of GTPase activity establishment of protein localization regulation of long-term neuronal synaptic plasticity positive regulation of synaptic transmission neuromuscular process controlling balance dendritic spine morphogenesis vocalization behavior AMPA glutamate receptor clustering regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential regulation of grooming behavior ureteric bud development cell adhesion protein localization regulation of protein localization nucleotide phosphorylation tissue morphogenesis positive regulation of multicellular organism growth positive regulation of developmental growth neuronal ion channel clustering locomotory behavior response to cocaine regulation of neuronal synaptic plasticity embryo development cell-cell adhesion neurotransmitter receptor localization to postsynaptic specialization membrane
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