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Antibodies Inc
Pan-PTPR (Receptor-Type Tyrosine-Protein Phosphatase) Monoclonal Antibody (N165/43), FL650
Product Details
75-194-FL650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
N165/43
Immunogen
Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (accession number P10586) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
655/676 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Pan-PTPR refers to the collective group of Protein Tyrosine Phosphatase Receptor (PTPR) family members, which are enzymes that dephosphorylate tyrosine residues on proteins. These receptors play key roles in regulating a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Their dysregulation is often associated with various diseases, including cancer and autoimmune disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LAR; LAR-PTP2; LCA-homolog; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; Leukocyte common antigen related; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase receptor-type F; protein tyrosine phosphatase, receptor type, D; protein tyrosine phosphatase, receptor type, delta polypeptide; protein tyrosine phosphatase, receptor type, F polypeptide; protein tyrosine phosphatase, receptor type, S; Protein-tyrosine phosphatase delta; PTPNU-3; R-PTP-delta; R-PTP-S; R-PTP-sigma; receptor-linked protein-tyrosine phosphatase LAR; Receptor-type tyrosine-protein phosphatase delta; Receptor-type tyrosine-protein phosphatase F; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; tissue-specific protein tyrosine phosphatase
Gene Aliases: 1110002J03Rik; 3000002J10Rik; AA591035; AL022616; B230219D21Rik; BNAH2; HPTP; HPTPD; HPTPDELTA; LAR; LARFN5C; Larptp2; LARS; PTP; PTP-NU3; PTPD; PTPNU-3; PTPRD; PTPRF; PTPRS; PTPSIGMA; Ptpsigma.; Ptpt9; R-PTP-delta; R-PTP-S; R-PTP-sigma; RPTP-LAR; Rptpd; RPTPDELTA; RPTPsigma
UniProt ID: (Human) P23468, (Human) P10586, (Human) Q13332, (Mouse) Q64487, (Rat) Q64604, (Mouse) A2A8L5, (Mouse) B0V2N1, (Rat) Q64605
Entrez Gene ID: (Human) 5789, (Human) 5792, (Human) 5802, (Mouse) 19266, (Rat) 313278, (Rat) 360406, (Mouse) 19268, (Mouse) 19280, (Rat) 25529
transmembrane receptor protein tyrosine phosphatase activity
receptor binding
protein binding
cell adhesion molecule binding
protein tyrosine phosphatase activity
heparin binding
protein complex binding
chondroitin sulfate proteoglycan binding
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
insulin receptor binding
receptor tyrosine kinase binding
phosphate ion binding
protein phosphatase
protein modifying enzyme
protein dephosphorylation
phosphate-containing compound metabolic process
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
transmembrane receptor protein tyrosine phosphatase signaling pathway
chemical synaptic transmission
neuron differentiation
peptidyl-tyrosine dephosphorylation
positive regulation of dendrite morphogenesis
presynaptic membrane assembly
cell adhesion
cell migration
neuron projection regeneration
regulation of axon regeneration
negative regulation of receptor binding
spinal cord development
cerebellum development
hippocampus development
cerebral cortex development
corpus callosum development
establishment of endothelial intestinal barrier
dephosphorylation
negative regulation of JAK-STAT cascade
regulation of immune response
negative regulation of cytokine-mediated signaling pathway
homophilic cell adhesion via plasma membrane adhesion molecules
nervous system development
negative regulation of cell proliferation
regulation of neuron projection development
negative regulation of cell projection organization
negative regulation of epidermal growth factor receptor signaling pathway
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of insulin receptor signaling pathway
regulation of synapse structure or activity
negative regulation of neurotrophin TRK receptor signaling pathway
signal transduction
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