PA5-16481 targets Cadherin Pan in IHC (P) applications and shows reactivity with mouse, Non-human primate, Rat, Xn, Bovine, Canine, Chicken, and Human samples. This antibody recognizes Cadherin E, N, P and R (Cadherin 1, 2, 3 and 4).
The PA5-16481 immunogen is a synthetic peptide from the C-terminal end of chicken N-cadherin.
Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARC-1; ATP-dependent helicase CHD1; ATP-dependent helicase CHD3; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 2; cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; CHD-1; CHD-3; Chromodomain-helicase-DNA-binding protein 1; Chromodomain-helicase-DNA-binding protein 3; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; E-Cadherin; E-cadherin 1; Epithelial cadherin; hZFH; L-CAM; Liver cell adhesion molecule; liver cell adhesion protein; Maternally-expressed neural cadherin; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; N-cadherin; N-cadherin 1; Neural cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; Uvomorulin; XmN-cadherin; xTCAD-1; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Aliases: 2600010P09Rik; 4930525N21Rik; AA960649; AF020312; AI385538; AI851787; Arc-1; AW120700; AW555109; BOS_17031; BOS_17249; BOS_22126; BOS_8518; CAD4; Cadherin-1; Cadp; CD324; CD325; CDH1; CDH15; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; Chd-1; CHD1; CHD3; Chd7; E-cad; ECAD; HJMD; K-CAM; L-CAM; LCAM; Mi-2a; Mi2-ALPHA; N-cadherin; NCAD; P-cadherin; PCAD; Prp7; Prp9-1; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO; Uvomorulin; XELAEV_18024918mg; XELAEV_18046239mg; ZFH
UniProt ID: (Chicken) P08641, (Bovine) Q6R8F2, (Dog) F1PAA9, (Human) P12830, (Chicken) P10288, (Human) P19022, (Human) P22223, (Bovine) P19535, (Chicken) P24503, (Human) P55283, (Human) O14646, (Human) Q12873, (Rat) Q9R0T4, (Mouse) P09803, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038, (Mouse) P40201, (Xenopus) P79883, (Xenopus) P30944
Entrez Gene ID: (Chicken) 415860, (Bovine) 282637, (Dog) 442858, (Human) 999, (Bovine) 281062, (Dog) 480169, (Chicken) 414745, (Human) 1000, (Dog) 611010, (Human) 1001, (Chicken) 414845, (Bovine) 281063, (Chicken) 419222, (Dog) 100685099, (Human) 1002, (Human) 1105, (Bovine) 505123, (Dog) 488891, (Bovine) 532673, (Human) 1107, (Dog) 479489, (Rat) 83502, (Mouse) 12550, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588, (Mouse) 12648, (Rat) 308215, (Rat) 303241, (Mouse) 216848, (Xenopus) 108702627, (Xenopus) 100337618