A suggested positive control is human ovary tissue lysate.
PA5-34475 can be used with blocking peptide PEP-1517.
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
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Protein Aliases: innexin; MRS1; Pannexin 1; Pannexin-1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
Gene Aliases: AI847747; MRS1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028