|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, corresponding to the N-terminal extracellular domain of human Parathyroid Hormone Rec. 1.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.7|
|Contains||0.01% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-20597 detects Parathyroid Hormone Rec. 1 in human samples.
PA1-20597 has been successfully used in immunohistochemistry (paraffin) procedures.
The PA1-20597 immunogen is a synthetic peptide, corresponding to the N-terminal extracellular domain of human Parathyroid Hormone Rec. 1.
Parathyroid hormone receptor 1 is a member of the G-protein coupled receptor family. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Parathyroid hormone receptor 1 has been reported to be expressed in bone, breast, brain, colon, GI, kidney, liver, placenta, skin, umbilical cord, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.