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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||A 23 amino acid peptide of the hPTH/PTHrP receptor which is not shared by the type II receptor|
|Storage buffer||PBS, pH 7.4, with 0.2% BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||2-4 µg/ml|
|Western Blot (WB)||1-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
MA5-11809 targets Parathyroid Hormone Receptor Type 1 in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-11809 immunogen is a 23 amino acid peptide of the hPTH/PTHrP receptor which is not shared by the type II receptor.
Two human parathyroid hormone (hPTH) receptors are known: one that binds both hPTH and a PTH-related protein called PTHrP (the Type I receptor); and one that only binds hPTH (the Type II receptor).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines.
MA5-11809 was used in immunohistochemistry to study the role of human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 in medulloblastoma-derived cell lines
|Gessi M,Monego G,Calviello G,Lanza P,Giangaspero F,Silvestrini A,Lauriola L,Ranelletti FO||Acta neuropathologica (114:135)||2007|
parathyroid hormone receptor 1; parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; seven transmembrane helix receptor
PFE; PTH1R; PTHR; PTHR1