Parkin Polyclonal Antibody

G-protein coupled receptor binding transcription corepressor activity actin binding ubiquitin-protein transferase activity protein binding beta-catenin binding zinc ion binding tubulin binding transferase activity SH3 domain binding enzyme binding kinase binding protein kinase binding PDZ domain binding Hsp70 protein binding heat shock protein binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding identical protein binding histone deacetylase binding ubiquitin binding phospholipase binding macromolecular complex binding metal ion binding chaperone binding ubiquitin protein ligase activity cullin family protein binding ubiquitin-specific protease binding F-box domain binding

negative regulation of transcription from RNA polymerase II promoter protein polyubiquitination mitochondrial fission mitophagy mitophagy synaptic transmission, dopaminergic startle response ubiquitin-dependent protein catabolic process protein monoubiquitination autophagy response to oxidative stress response to unfolded protein mitochondrion organization central nervous system development learning locomotory behavior adult locomotory behavior response to xenobiotic stimulus positive regulation of catabolic process proteasomal protein catabolic process regulation of autophagy positive regulation of gene expression negative regulation of gene expression positive regulation of mitochondrial fusion negative regulation of mitochondrial fusion regulation of mitochondrion organization regulation of glucose metabolic process positive regulation of mitochondrial membrane potential free ubiquitin chain polymerization regulation of dopamine secretion response to muscle activity macroautophagy protein ubiquitination protein deubiquitination regulation of anatomical structure morphogenesis protein catabolic process regulation of protein ubiquitination regulation of protein stability protein destabilization negative regulation of actin filament bundle assembly regulation of lipid transport positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of glucokinase activity cellular response to oxidative stress cellular response to unfolded protein response to endoplasmic reticulum stress synaptic transmission, glutamatergic protein K29-linked ubiquitination positive regulation of insulin secretion involved in cellular response to glucose stimulus ERAD pathway regulation of dopamine metabolic process norepinephrine metabolic process dopamine metabolic process regulation of apoptotic process positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of neuron apoptotic process mitochondrial fragmentation involved in apoptotic process protein K27-linked ubiquitination negative regulation by host of viral genome replication positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of insulin secretion regulation of neurotransmitter secretion modulation of synaptic transmission protein stabilization response to corticosterone positive regulation of neurotransmitter uptake dopamine uptake involved in synaptic transmission mitochondrion localization protein autoubiquitination regulation of mitochondrial membrane potential negative regulation of synaptic transmission, glutamatergic regulation of necroptotic process regulation of canonical Wnt signaling pathway parkin-mediated mitophagy in response to mitochondrial depolarization regulation of biological quality neuron cellular homeostasis protein K63-linked ubiquitination protein localization to mitochondrion aggresome assembly protein K48-linked ubiquitination protein K11-linked ubiquitination cellular response to manganese ion regulation of primary metabolic process protein K6-linked ubiquitination negative regulation of canonical Wnt signaling pathway positive regulation of mitochondrial fission negative regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission negative regulation of excitatory postsynaptic potential cellular response to toxic substance regulation of postsynaptic membrane neurotransmitter receptor levels mitochondrion to lysosome transport regulation protein catabolic process at presynapse regulation of synaptic vesicle endocytosis regulation of cellular response to oxidative stress positive regulation of mitophagy positive regulation of proteasomal protein catabolic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator positive regulation of protein linear polyubiquitination regulation of synaptic vesicle transport regulation of protein targeting to mitochondrion positive regulation of tumor necrosis factor-mediated signaling pathway cellular response to dopamine negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of reactive oxygen species biosynthetic process regulation of secretion by cell negative regulation of exosomal secretion positive regulation of dendrite extension negative regulation of spontaneous neurotransmitter secretion response to curcumin cellular response to L-glutamine cellular response to hydrogen sulfide positive regulation of type 2 mitophagy cellular response to L-glutamate positive regulation of retrograde transport, endosome to Golgi negative regulation of intralumenal vesicle formation positive regulation of protein localization to membrane amyloid fibril formation regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process positive regulation of ATP biosynthetic process