This Antibody was verified by KnockOut to ensure that the antibody binds to the antigen stated. View Details
This antibody is predicted to react with Monkey, Rat, Pig, Mouse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Parkinson's disease, the second most common neurodegenerative disease after Alzheimer's disease, is characterized by the loss of dopaminergic neurons and the presence of Lewy bodies (comprised of alpha-synuclein and parkin inclusions). Autosomal Recessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson's disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING-type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Studies show that parkin interacts with and ubiquitinates the alpha-synuclein interacting protein, synphilin-1. Recent analysis of parkin mutations in AR-JP patients reveals that parkin becomes functionally inactive as an E3 enzyme. This suggests that the loss of function mutation within parkin results in a failure of ubiquitin/proteasome-mediated proteolysis of synphilin-1 and the accumulation of proteins within the cell resulting in neuronal cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase parkin; PARK2; Parkin; parkin protein; Parkin RBR E3 ubiquitin-protein ligase; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; Parkinson disease protein 2; Parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Gene Aliases: AR-JP; LPRS2; Park; PARK2; PDJ; PRKN