This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated. View Details
MA5-13356 targets Paxillin in IF, IHC (P), IP, and WB applications and shows reactivity with Human and Rat samples.
The MA5-13356 immunogen is purified recombinant full-length human paxillin protein.
Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Protein Aliases: FLJ16691; hCG_1778014; myocardial ischemic preconditioning associated protein 7; PAX-1; PAXI; Paxillin; paxillin alpha; testicular tissue protein Li 134
Gene Aliases: AW108311; AW123232; Pax; PXN
Molecular Function: actin or actin-binding cytoskeletal protein