Note: You clicked on an external link, which has been disabled in order to keep your shopping session open.
|Tested species reactivity||Human, Mouse|
|Published species reactivity||Rat, Virus, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the N-terminal region of the human and mouse Pen-2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 6 publications below|
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.
36-7100 was used in western blot to assess the effects of presenilin dosage on cortical neuron survival in mice.
|Watanabe H,Iqbal M,Zheng J,Wines-Samuelson M,Shen J||The Journal of neuroscience : the official journal of the Society for Neuroscience (34:15912)||2014|
|Mouse||Not Cited||Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue.||Matsushima T,Saito Y,Elliott JI,Iijima-Ando K,Nishimura M,Kimura N,Hata S,Yamamoto T,Nakaya T,Suzuki T||The Journal of biological chemistry (287:19715)||2012|
Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.
36-7100 was used in western blot to study the effects of a familial frontotemporal dementia-associated presenilin- c.548G>T mutation in knock-in mice.
|Watanabe H,Xia D,Kanekiyo T,Kelleher RJ,Shen J||The Journal of neuroscience : the official journal of the Society for Neuroscience (32:5085)||2012|
|Mouse||1:200||Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.||Puccio S,Chu J,Praticò D||PloS one (6:null)||2011|
|Mouse||1:200||5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.||Chu J,Praticò D||Annals of neurology (69:34)||2011|
|Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB.||Wang R,Zhang YW,Sun P,Liu R,Zhang X,Zhang X,Xia K,Xia J,Xu H,Zhang Z||Molecular and cellular biology (26:1347)||2006|
gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN-2; PEN2; presenilin enhancer 2 homolog; presenilin enhancer gamma secretase subunit; presenilin enhancer protein 2
1700023M09Rik; MDS033; MSTP064; PEN-2; PEN2; PSENEN