|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG2b|
|Conjugate||Alexa Fluor® 647|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Perforin is one of the major cytolytic proteins of cytolyic granules. One of the main pathways of lymphocyte mediated cytolysis entails the secretion onto target membranes of cytolytic granules contained in cytolytic effector lymphocytes of T-cell or NK-cell type. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Perforin (PRF) is involved in the killing mediated by cytotoxic lymphocytes which represents an important mechanism of transmembrane channel formation similar to C9 and homology between perforin and C9 has been demostrated at their respective functionally conserved regions. Studies show that perforin is expressed only in killer cell lines and not in helper T lymophocytes or other tumor cells tested.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.