|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein corresponding to C-terminal region of human perforin|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 6 publications below|
MA5-12469 targets Perforin in IHC (P) applications and shows reactivity with Human samples.
The MA5-12469 immunogen is recombinant protein corresponding to C-terminal region of human perforin.
Perforin is a potent cytolytic pore-forming protein. It is a specific marker of functionally active cytotoxic T-lymphocytes (CTLs) and natural killer (NK) cells. Perforin is a key effector mechanisms in T cell-mediated cytotoxicity. It mediates cytolysis of target cells by membrane damage and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Functions of liver natural killer cells are dependent on the severity of liver inflammation and fibrosis in chronic hepatitis C.
MA5-12469 was used in immunohistochemistry to study the role of intra-hepatic natural killer cells during HCV infection and the influence of disease severity
|Fugier E,Marche H,Thélu MA,Macek Jílková Z,Van Campenhout N,Dufeu-Duchesne T,Leroy V,Zarski JP,Sturm N,Marche PN,Jouvin-Marche E||PloS one (9:null)||2014|
Immunohistochemical expression of granzyme B and perforin in discoid lupus erythematosus.
MA5-12469 was used in immunohistochemistry to study the clinicopathological significance of the expression of perforin and granzyme B in patients with discoid lupus erythematosus
|Abdou AG,Shoeib M,Bakry OA,El-Bality H||Ultrastructural pathology (37:408)||2013|
Primary angiitis of the central nervous system: 2 atypical cases.
MA5-12469 was used in immunohistochemistry to report on two atypical cases of primary angiitis of the central nervous system
|Pagni F,Isimbaldi G,Vergani F,Casiraghi P,Marzorati L,Migliorino G,Cattoretti G||Folia neuropathologica (50:293)||2012|
Adrenal extranodal NK/T-cell lymphoma diagnosed by fine-needle aspiration and cerebrospinal fluid cytology and immunophenotyping: a case report.
MA5-12469 was used in immunohistochemistry to report on a case of adrenal extranodal NK/T-cell lymphoma
|Dunning KK,Wudhikarn K,Safo AO,Holman CJ,McKenna RW,Pambuccian SE||Diagnostic cytopathology (37:686)||2009|
Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report.
MA5-12469 was used in immunohistochemistry to report on a colon cancer patient treated with repeated infusions of ex vivo TKD/IL-2-activated NK cells
|Milani V,Stangl S,Issels R,Gehrmann M,Wagner B,Hube K,Mayr D,Hiddemann W,Molls M,Multhoff G||Journal of translational medicine (7:null)||2009|
GMP-17-positive T-lymphocytes in renal tubules predict progression in early stages of IgA nephropathy.
MA5-12469 was used in immunohistochemistry to investigate the predictive value of GMP-17-positive T-lymphocytes in IgA nephropathy
|van Es LA,de Heer E,Vleming LJ,van der Wal A,Mallat M,Bajema I,Bruijn JA,de Fijter JW||Kidney international (73:1426)||2008|