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Localization of phosphatidylinositol 3,4,5-triphosphate in unstimulated (left panel) and insulin-stimulated (right panel) 3T3-L1 cells detected using anti–phosphatidylinositol 3,4,5-triphosphate, mouse IgM monoclonal RC6F8 (Cat. no. A21328) and visualized using biotinylated goat anti–mouse IgM in conjunction with Alexa Fluor® 488 streptavidin (Cat. no. S11223). Image courtesy of Echelon Research Laboratories, Inc.
|Tested species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgM|
|Storage buffer||PBS, pH 7.2, with 0.1% BSA|
|Contains||5mM sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Recent research has revealed direct actions of phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) on a diverse array of cellular functions including actin assembly and cytoskeletal dynamics, vesicular protein trafficking, protein kinase localization and activation, cell proliferation and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
4; 5)-trisphosphate; 5-triphosphate; Phosphatidylinositol (3; Phosphatidylinositol 3; PIP3