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Western blot analysis of Phospho-AR-beta-2 pSer346 using Phospho-AR-beta-2 pSer346 polyclonal antibody (Product # PA5-36784) at a dilution of 1:500. Lane 1: HepG2 cell lysate treated with PMA (100nM, 30min), Lane 2: Mouse spleen tissue lysate, Lane 3: Rat spleen tissue lysate.
|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phosphopeptide derived from human AR-beta2 around the phosphorylation site of Serine 346|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody detects endogenous protein at a molecular weight of 47 kDa, 68 kDa (glycosylated) and 95 kDa (Dimer).
Purity is >95% by SDS-PAGE.
Beta 2 Adrenergic Receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. Expression of the beta 2 Adrenergic Receptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ADRB2; ADRB2R; ADRBR; Adrenergic beta 2- receptor surface; adrenergic receptor, beta 2; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2 surface; adrenoceptor beta 2, surface; AR beta2; B2AR; BAR; beta 2-AR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; BETA2AR; catecholamine receptor
Adrb-2; ADRB2; ADRB2R; ADRBR; B2AR; Badm; BAR; BETA2AR; Gpcr7