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      View (23) other ATF2 antibodies

      Invitrogen

      Phospho-ATF2 (Thr69) Polyclonal Antibody

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      Catalog #:PA5-36622

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      Product Details

      TESTED APPLICATIONS DILUTION
      Immunohistochemistry (Paraffin) (IHC (P)) 1:50-1:200
      Immunoprecipitation (IP) Assay-Dependent
      Western Blot (WB) 1:500-1:1000
      Tested Species reactivity Human, Mouse, Rat
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic phosphopeptide derived from human ATF2 around the phosphorylation site of Threonine 69
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer PBS, pH 7.2
      Contains 0.05% sodium azide
      Storage conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
      RRID AB_2553619

      Product Specific Information

      This antibody detects endogenous protein at a molecular weight of 55-75 kDa.

      Purity is >95% by SDS-PAGE.

      Background/Target Information

      The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Bioinformatics

      Protein Aliases: Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; ATF-2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CREB-2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; Cyclic AMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; MXBP protein

      Gene Aliases: Atf-2; ATF2; CRE-BP; CRE-BP1; CREB-2; CREB2; CREBP1; D130078H02Rik; D18875; HB16; mXBP; Tg(Gzma-Klra1)7Wum; TREB7

      UniProt ID: (Human) P15336, (Mouse) P16951, (Rat) Q00969

      Entrez Gene ID: (Human) 1386, (Mouse) 11909, (Rat) 81647

      Molecular Function: nucleic acid binding transcription factor

      Function(s) Blue Arrow Icon
      negative regulation of transcription from RNA polymerase II promoter outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to osmotic stress cellular response to DNA damage stimulus response to water deprivation histone acetylation intra-S DNA damage checkpoint positive regulation of transforming growth factor beta2 production positive regulation of neuron apoptotic process fat cell differentiation positive regulation of transcription from RNA polymerase II promoter negative regulation of epithelial cell proliferation regulation of sequence-specific DNA binding transcription factor activity positive regulation of sequence-specific DNA binding transcription factor activity adipose tissue development amelogenesis positive regulation of mitochondrial membrane permeability involved in apoptotic process transcription, DNA-templated
      Process(es) Blue Arrow Icon
      RNA polymerase II regulatory region sequence-specific DNA binding
       RNA polymerase II distal enhancer sequence-specific DNA binding
       transcription factor activity, RNA polymerase II transcription factor binding
       transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
       RNA polymerase II activating transcription factor binding
       enhancer sequence-specific DNA binding
       transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
       chromatin binding
       transcription factor activity, sequence-specific DNA binding
       transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
       transcription coactivator activity
       histone acetyltransferase activity
       protein binding
       cAMP response element binding protein binding
       protein kinase binding
       cAMP response element binding
       metal ion binding
       protein heterodimerization activity
       nucleic acid binding
       DNA binding
       transferase activity
       sequence-specific DNA binding

      Suggested Secondary Antibodies

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