Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%).
Positive Control: Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2, 293T (starvation for 16 hr and 0.5 uM Oligomycin treatment for 30 min).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acaca; ACC-alpha; ACC1; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 265; Acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase; EC 188.8.131.52; EC 184.108.40.206
Gene Aliases: A530025K05Rik; ACAC; ACACA; ACACAD; ACC; ACC1; ACCA; Gm738
Molecular Function: ligase