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Fabgennix
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
ELISA (ELISA) |
1:10,000 | - |
Immunoprecipitation (IP) |
1:50-1:250 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Bovine, Human, Mouse, Sheep, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide taken within amino acid region 200-240 on rat Aquaporin 2 protein. Phosphorylated Serine 218 residue. |
Conjugate |
FITC |
Excitation/Emission Profile |
View spectra
|
Form |
Liquid |
Concentration |
0.5-1.5 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, store in dark |
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQPCD; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin-2; Aquaporin-CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCH-CD; WCHCD
Gene Aliases: AQP-2; AQP-CD; AQP2; aquaporin-2; cph; jpk; WCH-CD
UniProt ID: (Human) P41181, (Bovine) P79099, (Mouse) P56402, (Rat) P34080
Entrez Gene ID: (Human) 359, (Sheep) 443024, (Bovine) 539870, (Mouse) 11827, (Rat) 25386
Molecular Function:
transporter
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