This antibody is predicted to react with bovine, canine and mouse based on 100% sequence homology.
PA5-35388 is specific for the ~29kDa AQP2 protein phosphorylated at Ser269, and also recognizes the glycosylated form of AQP2 at ~37kDa. This antibody contains enough material to conduct 10 mini-Western blots.
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQPCD; Aquaporin CD; Aquaporin-2; Aquaporin-CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; WCH CD; WCH-CD; WCHCD
Gene Aliases: AQP-2; Aqp2; aquaporin-2
UniProt ID: (Rat) P34080
Entrez Gene ID: (Rat) 25386
Molecular Function: transporter