|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human AurB/C around the phosphorylation site of Thr236/202 (C-G-TP-L-D)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 150mM NaCl, 50% glycerol|
|Contains||0.02% sodium azide|
Aurora kinases belong to a highly conserved family of mitotic serine/threonine kinases with three members identified among mammals: Aurora A, B, and C. Studies on the temporal expression pattern and subcellular localization of Aurora kinases in mitotic cells suggest an association with mitotic structure. Aurora kinase functional influences span from G2 phase to cytokinesis and may be involved in key cell cycle events such as centrosome duplication, chromosome bi-orientation and segregation, cleavage furrow positioning, and ingression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AIE2; AIK2; AIK3; AIM1; AIRK3; ARK-3; ARK2; ARK3; AURKB; AURKC; Aurora 3; aurora B; Aurora kinase C; Aurora-related kinase 2; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; aurora/Ipl1/Eg2 protein 1; Aurora/IPL1/Eg2 protein 2; epididymis secretory protein Li 90; serine/threonine kinase 13 (aurora/IPL-like); serine/threonine kinase 13 (aurora/IPL1-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; STK12; STK13; STK5
Gene Aliases: AIE1; AIE2; AIK3; AIRK3; ARK-3; ARK3; AurC; AURKC; aurora-C; HEL-S-90; IAK3; SPGF5; STK13
UniProt ID: (Human) Q9UQB9
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