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|Tested species reactivity||Rat, Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human BCL-2 around the phosphorylation site of Serine 87|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Apoptosis regulator Bcl-2; B cell lymphoma 2 associated oncogene; B-cell leukemia/lymphoma 2; BCL2; Bcl2-like protein; protein phosphatase 1, regulatory subunit 50
AW986256; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik; PPP1R50