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Invitrogen

Phospho-BMAL1 (Ser42) Polyclonal Antibody

View all (29) BMAL1 antibodies

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Phospho-BMAL1 (Ser42) Polyclonal Antibody

Product Details

PA5-104579

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ARNTL(Accession O00327), corresponding to amino acid residues around phosphorylated Ser42.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816054

Product Specific Information

Antibody detects endogenous levels of BMAL1 only when phosphorylated at Ser42.

Target Information

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ARNT-like protein 1, brain and muscle; Arnt3; aryl hydrocarbon receptor nuclear translocator like; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix-loop-helix ARNT-like protein 1; basic helix-loop-helix family member e5; basic-helix-loop-helix-PAS orphan MOP3; Basic-helix-loop-helix-PAS protein MOP3; bHLH-PAS protein JAP3; bHLHe5; Brain and muscle ARNT-like 1; CG8727 PA; Class E basic helix-loop-helix protein 5; cycle; Member of PAS protein 3; member of PAS superfamily 3; MGC47515; mutant basic helix-loop-helix ARNT-like protein 1; PAS domain containing 3; PAS domain-containing protein 3; testis tissue sperm-binding protein Li 50e; Tic; unnamed protein product

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Gene Aliases: Arnt3; ARNTL; ARNTL1; BHLHE5; BMAL1; BMAL1b; bmal1b'; BMAL1c; JAP3; MOP3; PASD3; TIC

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UniProt ID: (Rat) Q9EPW1, (Mouse) Q9WTL8, (Human) O00327

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Entrez Gene ID: (Rat) 29657, (Mouse) 11865, (Human) 406

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Function(s)
transcription regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding signal transducer activity aryl hydrocarbon receptor binding bHLH transcription factor binding sequence-specific DNA binding protein heterodimerization activity protein dimerization activity Hsp90 protein binding E-box binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding protein binding transcription factor binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor activity DNA-binding transcription factor binding sequence-specific double-stranded DNA binding basic helix-loop-helix transcription factor
Process(es)
protein import into nucleus, translocation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter signal transduction spermatogenesis circadian rhythm negative regulation of TOR signaling circadian regulation of gene expression regulation of protein catabolic process regulation of hair cycle regulation of circadian rhythm positive regulation of circadian rhythm proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of neurogenesis regulation of insulin secretion regulation of cell cycle response to redox state positive regulation of canonical Wnt signaling pathway oxidative stress-induced premature senescence regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway regulation of cellular senescence positive regulation of skeletal muscle cell differentiation rhythmic process regulation of transcription from RNA polymerase II promoter energy homeostasis negative regulation of cold-induced thermogenesis positive regulation of protein acetylation
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