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Western blot analysis of Beta-catenin (Ser33/Ser37) in recombinant fusion protein containing 1) phosphorylated serine residues at positions 33 and 37 and 2) unphosphorylated serine residues at positions 33 and 37, using a Phospho-Beta-catenin pSer33+Ser37 polyclonal antibody (Product # PA5-23354) at 0.25 ug/ml.
|Tested species reactivity||Chicken, Human, Marsupial, Mouse, Primate, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (32 D(S)GIH(S)GATTTAPS 45) of Phospho-Beta-catenin pSer33/Ser37 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.25-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Beta-catenin, an adherens junction protein, was originally identified as a component of cell-cell adhesion structures. It interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Recent results show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of Beta-catenin has been identified in pilomatrixoma, medulloblastoma and tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
beta catenin; beta-catenin; beta-catenin-like protein 1; C20orf33; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta; catenin beta-1; dJ633O20.1; NAP; nuclear associated protein; nuclear-associated protein; NYD-SP19; P14L; PP8304; RP5-1118M15.1; testis development protein NYD-SP19
armadillo; Bfc; Catnb; CHBCAT; CTNNB; CTNNB1; Mesc; MRD19; OK/SW-cl.35; PRO2286