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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phospho-peptide surrounding the Blooms Syndrome Protein Blm threonine 99 region|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris HCl, pH 8.5, with 0.2M glycine|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Blooms Syndrome Protein Blm is a member of the RecQ helicase protein family. The protein contains 1417 amino acids; including one ATP binding site, one DEAH box, and two putative nuclear localization signals, as well as phosphorylation sites. Blooms Syndrome Protein Blm is known to associate and be phosphorylated by the ATR (ataxia telangiectasia, rad3+) protein, in response to genetic stress. This gene product is thought to play a role in the etiology of two major human health problems, each of which is a very common complication of Bloom's syndrome, namely cancer and diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bloom syndrome, RecQ helicase-like; BS; DNA helicase, RecQ-like type 2; recQ protein-like 3; RecQ-like type 2; RECQ2; RECQL2; RECQL3
BLM; BS; RECQ2; RECQL2; RECQL3