C-Jun/D-Jun are members of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
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Protein Aliases: Activator protein 1; AH119; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; enhancer-binding protein AP1; immediate early; Jun A; Jun activation domain binding protein; jun D proto-oncogene; Jun oncogene; jun proto-oncogene; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; JunD-FL isoform; p39; Proto-oncogene c-Jun; transcription factor; transcription factor AP-1; Transcription factor AP-1 subunit Jun; Transcription factor AP-1 subunit JunD; Transcription factor Jun; transcription factor jun-D; Transcription factor JunD; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
Gene Aliases: AP-1; AP1; c-Jun; fj36h07; JUN; Jun-d; Junc; JUND; Jund1; Rjg-9; si:dkey-251j8.3; wu:fj36h07; zgc:65863
Molecular Function: basic leucine zipper transcription factor