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Invitrogen

Phospho-C-Jun/D-Jun (Ser73, Ser100) Recombinant Rabbit Monoclonal Antibody (23GB4495)

View all (3) C-Jun/D-Jun antibodies

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Phospho-C-Jun/D-Jun (Ser73, Ser100) Recombinant Rabbit Monoclonal Antibody (23GB4495)

Product Details

MA5-52704

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunocytochemistry (ICC/IF)

1:1,000
-

Flow Cytometry (Flow)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293F

Class

Recombinant Monoclonal

Type

Antibody

Clone

23GB4495

Immunogen

A synthesized peptide derived from human Phospho-c-Jun (Ser73)+JunD (Ser100) (66-80AA).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3 mg/mL

Amount

300 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3249181

Target Information

C-Jun/D-Jun are members of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activator Protein 1; AH119; AP-1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; C-JUN; c-jun protein; CJUN; Enhancer-Binding Protein AP1; immediate early; JUN; jun A; Jun Activation Domain Binding Protein; jun D proto-oncogene; Jun Oncogene; jun proto-oncogene; Jun proto-oncogene related gene d; Jun proto-oncogene related gene d1; Jun Proto-Oncogene, AP-1 Transcription Factor Subunit; P39; proto-oncogene c-Jun; Proto-Oncogene CJun; Transcription Factor AP-1; Transcription Factor AP-1 Subunit Jun; transcription factor AP-1 subunit JunD; Transcription Factor Jun; transcription factor jun-D; unnamed protein product; V-Jun Avian Sarcoma Virus 17 Oncogene Homolog; v-jun sarcoma virus 17 oncogene homolog

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Gene Aliases: AP-1; AP1; c-Jun; cJUN; Junc; Jund1; p39

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UniProt ID: (Human) P05412, (Human) P17535, (Rat) P17325, (Mouse) P05627, (Mouse) P15066, (Rat) P52909

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Entrez Gene ID: (Human) 3725, (Human) 3727, (Rat) 24516, (Mouse) 16476, (Mouse) 16478, (Rat) 24518

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA binding GTPase activator activity protein binding enzyme binding ubiquitin protein ligase binding cAMP response element binding identical protein binding ubiquitin-like protein ligase binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding general transcription initiation factor binding sequence-specific double-stranded DNA binding transcription cofactor binding ligand-dependent nuclear receptor binding sequence-specific DNA binding protein homodimerization activity macromolecular complex binding HMG box domain binding transcription coactivator activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway JNK cascade release from viral latency transforming growth factor beta1 production response to endoplasmic reticulum stress regulation of cell proliferation negative regulation of DNA binding negative regulation by host of viral transcription positive regulation by host of viral transcription negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone regulation of cell cycle SMAD protein signal transduction cellular response to anisomycin integrated stress response signaling positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of vascular smooth muscle cell proliferation positive regulation of DNA-templated transcription, initiation angiogenesis microglial cell activation release of cytochrome c from mitochondria liver development positive regulation of endothelial cell proliferation outflow tract morphogenesis transcription, DNA-templated transcription from RNA polymerase II promoter immune response learning circadian rhythm positive regulation of cell proliferation negative regulation of cell proliferation response to xenobiotic stimulus response to mechanical stimulus positive regulation of epithelial cell migration monocyte differentiation axon regeneration negative regulation of protein autophosphorylation response to lipopolysaccharide response to insulin response to cytokine cellular response to zinc ion starvation leading edge cell differentiation response to muscle stretch response to hydrogen peroxide positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process response to ethanol positive regulation of monocyte differentiation positive regulation of DNA replication positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation cellular response to potassium ion starvation response to cAMP membrane depolarization eyelid development in camera-type eye positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to calcium ion cellular response to hypoxia response to forskolin cellular response to prolactin positive regulation of apoptotic signaling pathway osteoblast development response to cold response to water deprivation response to light stimulus gene expression negative regulation of cardiac muscle hypertrophy positive regulation of peroxisome proliferator activated receptor signaling pathway positive regulation of macrophage activation response to peptide hormone positive regulation of osteoblast differentiation response to mercury ion epithelial cell proliferation negative regulation of epithelial cell proliferation cellular response to fatty acid cellular response to polyamine macromolecule
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