|Tested species reactivity||Human|
|Published species reactivity||Cat, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from the c-terminus of the Integrin beta-3 receptor|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.1-1.0 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain.||Feire AL,Koss H,Compton T||Proceedings of the National Academy of Sciences of the United States of America (101:15470)||2004|
|Cat||Not Cited||Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src.||Willey CD,Balasubramanian S,Rodríguez Rosas MC,Ross RS,Kuppuswamy D||Journal of molecular and cellular cardiology (35:671)||2003|