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Western blot analysis of Phospho-CSF-1/MCSF Receptor pTyr809 in LPS-treated 293 whole cell lysates with a blocking peptide (lane 1) and no blocking peptide (lane 2) using a Phospho-CSF-1/MCSF Receptor pTyr809 polyclonal antibody (Product # PA5-35775).
|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from human M-CSF Receptor around the phosphorylation site of Tyrosine 809|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
c-fms; CD115 antigen; CSF-1 receptor; CSF-1-R; CSF1RC-FMSCD115CSF-1-RCSFREC 18.104.22.168FIM2FMS; FMS proto-oncogene; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; proto-oncogene c-Fms; proto-oncogene fms
AI323359; C-FMS; CD115; CSF-1-R; CSF-1R; Csfmr; CSFR; Fim-2; FIM2; FMS; HDLS; M-CSF-R; M-CSFR; mrfms
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Immunity and defense Stress response Oncogenesis Developmental processes Gametogenesis Embryogenesis Cell structure and motility Cell motility Cell proliferation and differentiation