CXCR2 is a receptor for interleukin-8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to GRO/MGSA and NAP-2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
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Protein Aliases: C-X-C chemokine receptor type 2; CD182; CD182 antigen; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (C-X-C) receptor 2; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 receptor alpha chain; Il-8 receptor b; IL-8 receptor beta; IL-8 receptor type 2; IL-8R B; Il-8rb; IL8R2; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
Gene Aliases: CD128; CD182; CDw128; CDw128b; CMKAR2; CXCR2; Gpcr16; IL-8rb; IL-8Rh; IL8R2; IL8RA; IL8RB; mIL-8RH
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor