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7TM Antibodies
Phospho-Cannabinoid Receptor 2 (Ser326) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Cannabinoid Receptor 2 (Ser326) Antibody (7TM0057C) in WB
Agonist-induced Serine326 phosphorylation of the Cannabinoid Receptor 2. Upper panel, HEK293 cells stably expressing the CB2-Receptor (CB2) were either not exposed or exposed to 1 µM of CB2-Receptor Agonists CP55940 or WIN55212-2 for 30 minutes. Cells were lysed and immunoblotted with the anti-pS326-CB2 antibody (7TM0057C) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with an phospho... View More
Product Details
7TM0057C
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human CB2 around the phosphorylation site of Ser326.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P/Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cannabinoid Receptor 2; cannabinoid receptor 2 (macrophage); CB-2; CB2R; CNR3; CX5; HCB2; HGNC:2160; OTTHUMP00000044841; RP11-4M23.1; testis-dominant CNR2 isoform CB2
Gene Aliases: CB-2; CB2; CB2A; CB2B; CNR2; CX5
UniProt ID: (Human) P34972
Entrez Gene ID: (Human) 1269
response to amphetamine
inflammatory response
immune response
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
sensory perception of pain
negative regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
cannabinoid signaling pathway
negative regulation of action potential
negative regulation of inflammatory response
negative regulation of nitric-oxide synthase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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