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7TM Antibodies
Phospho-Corticotropin-Releasing Factor Receptor 1 (Thr428, Ser429) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Corticotropin-Releasing Factor Receptor 1 (Thr428, Ser429) Antibody (7TM0212A) in WB
Agonist-induced Threonine344/Serine347 phosphorylation of NK1 Receptor. Upper panel, HEK293 cells stably expressing the NK1-Receptor (NK1) were either not exposed or exposed to 1 µM of specific NK1-Receptor Agonist Substance P for 30 minutes. Cells were lysed and immunoblotted with the anti-pT344/pS347-NK1 antibody (7TM0360A) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with the pho... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
7TM0212A
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human CRF1 around the phosphorylation site Thr428/Ser429.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: corticotropin-releasing factor receptor variant 1j; corticotropin-releasing factor type 1 receptor; Crf receptor 1; Crf type 1; Crf1 receptor; CRF1I; CRH-R1d; type 1 CRH receptor; CRH-R1h; CRHR1e; CRHR1f; CRHR1g; G protein-coupled receptor; seven transmembrane helix receptor
Gene Aliases: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L
UniProt ID: (Human) P34998
Entrez Gene ID: (Human) 1394
immune response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
female pregnancy
parturition
hormone-mediated signaling pathway
adrenal gland development
positive regulation of synaptic transmission, GABAergic
cellular response to hormone stimulus
fear response
regulation of transport
positive regulation of corticotropin secretion
general adaptation syndrome
general adaptation syndrome, behavioral process
cellular response to corticotropin-releasing hormone stimulus
negative regulation of voltage-gated calcium channel activity
regulation of corticosterone secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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